New Diagnostic & Therapeutic Target for Cardiovascular Disease

HBI Blog / New Diagnostic & Therapeutic Target for Cardiovascular Disease

A thorough study was published today in the journal Nature where scientists from Centro Nacional de Investigaciones Cardiovasculares (CNIC) have claimed to identify a mitochondrial protein.

What does it do?

This newly discovered protein will not only help as a potential marker for the diagnosis of cardiovascular disease but also work as a possible target for future treatments.

Cardiovascular Disease

The study shows that the mitochondrial protein ALDH4A1 is an autoantigen that is involved in atherosclerosis. Its involvement in atherosclerosis makes ALDH4A1 a possible therapeutic target or a diagnostic marker.

Study leader Dr. Almudena Ramiro said, “The study shows that ALDH4A1 accumulates in plaques and that its plasma concentration is elevated in the atherosclerosis-prone mice and human patients with carotid atherosclerosis, establishing ALDH4A1 as a possible biomarker of the disease.”

The study concludes while opening a new path to diagnostic and therapeutic interventions in cardiovascular disease.

Complete Abstract

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